Log In
Sign Up
3.3 15 hours ago Full Job Description Join the Spark Team We were born of innovation, springing from the curiosity, imagination and dedication of remarkable scientists and healthcare visionaries. Our shared mission is to challenge the inevitability of genetic disease by discovering, developing, and delivering treatments in ways unimaginable – until now. We don’t follow footsteps. We create the path. The In Vivo Research Associate will be responsible for performing In Vivo studies to support all CNS therapeutic areas and other therapeutic areas of the Non-Clinical department, if needed. Additional responsibilities include but are not limited to: Oversee and perform large numbers of in vivo studies concurrently and according to the experimental designs. Perform ICV/Intrathecal/Intraparenchymal/IV/IP/SC injections in mice and rats, monitor animal health, collect blood samples, collect CSF perform necropsies. Perform behavioral studies, brain surgeries as required. Maintain mouse breeding colonies. Ensure accurate data recording. General supplies and reagent inventory and ordering. Interact with CNS team scientists and provide constant feedback. Work crossfunctionally with liver and ocular teams and provide support to other R&D In Vivo needs. Perform In Vivo experiments and animal monitoring according to applicable regulations in support of the CNS team and other therapeutic areas. Maintain accurate record of procedures and provide results/comments to study directors Education and Experience Requirements Bachelor’s degree in relevant field and 3 years hands on experience with rodents required or equivalent experience is acceptable. Master’s degree preferred. Generally has 3-5+ years of hands on relevant experience with rodents Advanced skills on handling, restraining, dosing and performing a variety of procedures on study animals required. Ability to manage large mouse colonies required. Excellent organizational, communication and collaborative skills. Keep accurate records, follow instructions and comply with company policies. Experience with Gene Therapy is a plus Strong organizational skill. Strong self motivation, adaptability and positive attitude. Ability to learn new techniques, and multitask as needed. Excellent record keeping. Excellent writing and verbal communication skills. Experience with animal behavioral paradigms a plus. The In Vivo Research Associate will be responsible for performing In Vivo studies to support all CNS therapeutic areas and other therapeutic areas of the Non-Clinical department, if needed. Additional responsibilities include but are not limited to: Oversee and perform large numbers of in vivo studies concurrently and according to the experimental designs. Perform ICV/Intrathecal/Intraparenchymal/IV/IP/SC injections in mice and rats, monitor animal health, collect blood samples, collect CSF perform necropsies. Perform behavioral studies, brain surgeries as required. Maintain mouse breeding colonies. Ensure accurate data recording. General supplies and reagent inventory and ordering. Interact with CNS team scientists and provide constant feedback. Work cross functionally with liver and ocular teams and provide support to other R&D In Vivo needs. Responsibilities Perform In Vivo experiments and animal monitoring according to applicable regulations in support of the CNS team and other therapeutic areas. Maintain accurate record of procedures and provide results/comments to study directors Education and Experience Requirements Bachelor’s degree in relevant field and 3 years hands on experience with rodents required or equivalent experience is acceptable. Master’s degree preferred. Generally, has 3-5+ years of hands on relevant experience with rodents Advanced skills on handling, restraining, dosing and performing a variety of procedures on study animals required. Ability to manage large mouse colonies required. Excellent organizational, communication and collaborative skills. Keep accurate records, follow instructions and comply with company policies. Experience with Gene Therapy is a plus. Key Skills, Abilities, and Competencies Strong organizational skills. Strong self-motivation, adaptability and positive attitude. Ability to learn new techniques and multitask as needed. Excellent record keeping. Excellent writing and verbal communication skills. Experience with animal behavioral paradigms a plus. Complexity and Problem Solving Demonstrate independent problem solving skills of technical issues; develop solutions to a variety of moderate to complex problems; Discuss with supervisor and refer to policies/practices for guidance. Must be comfortable in the fast-paced, biotech start-up environment and interact with multi-disciplinary research teams at Spark. Exercise judgment within defined procedures and practices to determine appropriate action. Please be aware that Spark mandates COVID-19 vaccination of all employees regardless of work location. Accommodations may be made in accordance with applicable law.